The invention provides an aluminum electrolysis inert anode of which the material is a high-entropy alloy. The high-entropy alloy contains 5-10 alloy elements of which the mole ratio can be identical or different; and the atomic percent of each main element is 5-35%. The high-entropy alloy inert anode has the characteristics of favorable high-temperature oxidation resistance, high aluminum electrolysis salt corrosion resistance, high electric conductivity and the like. The high-entropy alloy prepared by the smelting method has the advantages of simple technique and low cost, and is easy for connection. When being used for aluminum electrolysis, the high-entropy alloy can avoid the consumption of the carbon anode and the emission of the CO2 gas, and has the advantages of energy saving and emission reduction.